NMI and GCSH

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NMI	GCSH
Description		N-myc and STAT interactor	glycine cleavage system protein H
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Identical Protein Binding	Aminomethyltransferase Activity Protein Binding
	Biological Process	Macrophage Activation Involved In Immune Response Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K48-linked Ubiquitination	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System
Pathways			Glyoxylate metabolism and glycine degradation Glycine degradation
Drugs			6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Blood protein levels ( 28240269)	Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		58 interacting genes: BRAT1 BRCA1 BRMS1 C1orf216 C9orf72 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EXOSC5 GCSH GOLGA8EP HDDC3 HGS HHLA3 HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN MYOM3 NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 THAP8 TRAF5 TRIM72 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I	10 interacting genes: CIDEB ING5 MAGEA11 MAGEA6 MED11 MIS18A NMI RHBDD2 SFI1 ZBTB16
Entrez ID		9111	2653
HPRD ID		04632	01998
Ensembl ID		ENSG00000123609	ENSG00000140905
Uniprot IDs		Q13287	P23434
PDB IDs
Enriched GO Terms of Interacting Partners?
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