GCSH and MED11

Data Source:
BioGRID (two hybrid)

		GCSH	MED11
Description		glycine cleavage system protein H	mediator complex subunit 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Ubiquitin Ligase Complex Mediator Complex
	Molecular Function	Aminomethyltransferase Activity Protein Binding	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination
Pathways		Glyoxylate metabolism and glycine degradation Glycine degradation	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: CIDEB ING5 MAGEA11 MAGEA6 MED11 MIS18A NMI RHBDD2 SFI1 ZBTB16	13 interacting genes: ABI2 APP CCDC120 GCSH MED22 MED8 MED9 NDEL1 NME7 SGF29 SSC5D SYCE2 USHBP1
Entrez ID		2653	400569
HPRD ID		01998	14709
Ensembl ID		ENSG00000140905	ENSG00000161920
Uniprot IDs		P23434	I3L3E8 Q9P086
PDB IDs
Enriched GO Terms of Interacting Partners?
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