GCSH and MIS18A

Data Source:
BioGRID (two hybrid)

		GCSH	MIS18A
Description		glycine cleavage system protein H	MIS18 kinetochore protein A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Aminomethyltransferase Activity Protein Binding	Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System	Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Regulation Of DNA Methylation Cell Division
Pathways		Glyoxylate metabolism and glycine degradation Glycine degradation	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs		6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: CIDEB ING5 MAGEA11 MAGEA6 MED11 MIS18A NMI RHBDD2 SFI1 ZBTB16	30 interacting genes: ABI3 AIMP2 AMOT ATG14 BRD8 C1orf216 CCDC115 CNGA3 DMAP1 FNDC11 GCSH GLYCTK HJURP IFT20 MAFIP MBIP NDEL1 NTAQ1 NUP58 OIP5 PPP1R13B RTP5 STX11 STX17 TEDC2 THAP1 TSGA10IP TXLNA ZNF471 ZNF655
Entrez ID		2653	54069
HPRD ID		01998	10749
Ensembl ID		ENSG00000140905	ENSG00000159055
Uniprot IDs		P23434	Q9NYP9
PDB IDs
Enriched GO Terms of Interacting Partners?
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