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PIAS2 and HUWE1
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
PIAS2
HUWE1
Description
protein inhibitor of activated STAT 2
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
DNA Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Protein Sumoylation
Negative Regulation Of Androgen Receptor Signaling Pathway
Protein Polyubiquitination
Base-excision Repair
Protein Monoubiquitination
Golgi Organization
Negative Regulation Of Mitochondrial Fusion
Protein Ubiquitination
Histone Ubiquitination
Cell Differentiation
Positive Regulation Of Protein Ubiquitination
Circadian Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neutrophil Degranulation
Positive Regulation Of Protein Catabolic Process
Membrane Fusion
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Neutrophil degranulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Fruit consumption (
32066663
)
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Educational attainment (years of education) (
30038396
)
Interacting Genes
125 interacting genes:
ACY3
ADA
AKT1
AR
ATF2
C1QA
C5orf24
CBS
CBSL
CCHCR1
CCNDBP1
CDCA8
CGGBP1
CHMP4B
CLDN2
CREB1
CREBBP
CTBP1
DDX39B
DES
DEUP1
DMC1
DNMT3A
EDC3
ELK1
ESR1
ESR2
EXOSC8
FAM118B
FKBP6
FLI1
GFAP
GLUL
GOLGA2
GRHL2
GRM8
GTF2I
GTF2IRD1
HDAC3
HMBOX1
HMG20A
HMG20B
HMGXB4
HNRNPCL1
HNRNPUL1
HOMER1
HOOK1
HUWE1
IKZF1
IMPDH1
JUN
KIFC3
LCE1E
LCE2C
LMNA
LMNB1
MAPK8
MAPKAPK2
MBD1
MITF
MLX
MSX2
MX1
MX2
NAV2
NME7
NR3C1
PAICS
PARK7
PAXIP1
PGR
PHC1
PIAS1
PIAS4
PLAG1
PLAGL1
PML
PRKAB2
PRKRA
PRPH
RFX2
RUFY1
RUNX1T1
SEC23A
SIAH1
SIAH2
SMAD3
SMAD4
SNAI2
SNIP1
SOX5
SPATC1L
SPINDOC
SREBF2
STAT4
SUMO1
SUMO1P1
SUMO2
SUMO3
SYN3
TH
TICAM2
TP53
TRAF2
TRAF3
TRAF5
TRIM23
TRIM27
TRIM50
TRIM55
TRIM63
TSR2
TXLNA
UBASH3B
UBE2I
UBE2L3
UBQLN1
ZBED1
ZBTB16
ZBTB8A
ZC3H10
ZFP42
ZNF319
ZNF451
ZNRD2
36 interacting genes:
ABL1
ATOH1
CALM1
CCL1
CDKN2A
CTNNB1
CUL4B
ERG
H2AX
HDAC2
HSPB1
LAPTM5
MCL1
MYCN
PCNA
PIAS2
POLB
POLL
PPP5C
RBBP7
RNF11
SMAD2
SMAD9
SUMO2
TBP
TNS2
TP53
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2L3
USP4
USP7
WBP2
Entrez ID
9063
10075
HPRD ID
06944
06608
Ensembl ID
ENSG00000078043
ENSG00000086758
Uniprot IDs
A0A024RC49
O75928
Q2TA77
A0A024R9W5
Q7Z6Z7
PDB IDs
2ASQ
4FO9
2EKK
2MUL
3G1N
3H1D
5C6H
5LP8
6FYH
6MIW
6PFL
Enriched GO Terms of Interacting Partners
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