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PIAS2 and ADA
Data Source:
BioGRID
(two hybrid)
PIAS2
ADA
Description
protein inhibitor of activated STAT 2
adenosine deaminase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Extracellular Space
Lysosome
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Junction
Dendrite Cytoplasm
Neuronal Cell Body
Cytoplasmic Vesicle Lumen
Molecular Function
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
Purine Nucleoside Binding
Adenosine Deaminase Activity
Protein Binding
Zinc Ion Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Protein Sumoylation
Negative Regulation Of Androgen Receptor Signaling Pathway
Response To Hypoxia
Histamine Secretion
Trophectodermal Cell Differentiation
Liver Development
Placenta Development
Germinal Center B Cell Differentiation
Positive Regulation Of Germinal Center Formation
Negative Regulation Of Leukocyte Migration
Negative Regulation Of Mature B Cell Apoptotic Process
Adenosine Catabolic Process
Deoxyadenosine Catabolic Process
Cell Adhesion
Aging
Purine Ribonucleoside Monophosphate Biosynthetic Process
Positive Regulation Of Heart Rate
Positive Regulation Of B Cell Proliferation
Purine Nucleotide Salvage
Positive Regulation Of T Cell Differentiation In Thymus
Response To Vitamin E
Regulation Of Cell-cell Adhesion Mediated By Integrin
T Cell Activation
Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Response To Drug
Response To Hydrogen Peroxide
Purine-containing Compound Salvage
Hypoxanthine Salvage
Response To Morphine
Positive Regulation Of Smooth Muscle Contraction
DAMP Catabolic Process
DATP Catabolic Process
Inosine Biosynthetic Process
Xanthine Biosynthetic Process
Positive Regulation Of Alpha-beta T Cell Differentiation
Lung Alveolus Development
Peyer's Patch Development
Embryonic Digestive Tract Development
Negative Regulation Of Inflammatory Response
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Adenosine Receptor Signaling Pathway
Negative Regulation Of Penile Erection
Negative Regulation Of Thymocyte Apoptotic Process
Negative Regulation Of Mucus Secretion
Pathways
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Purine salvage
Drugs
Pentostatin
Dipyridamole
FR221647
7,8-dihydroinosine
FR117016
FR236913
6-hydroxy-1,6-dihydro purine nucleoside
FR-234938
FR239087
FR230513
1-Deaza-Adenosine
Nebularine
(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE
1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases
T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS
Fruit consumption (
32066663
)
Inflammatory bowel disease (
28067908
)
Ulcerative colitis (
28067908
23128233
)
Interacting Genes
125 interacting genes:
ACY3
ADA
AKT1
AR
ATF2
C1QA
C5orf24
CBS
CBSL
CCHCR1
CCNDBP1
CDCA8
CGGBP1
CHMP4B
CLDN2
CREB1
CREBBP
CTBP1
DDX39B
DES
DEUP1
DMC1
DNMT3A
EDC3
ELK1
ESR1
ESR2
EXOSC8
FAM118B
FKBP6
FLI1
GFAP
GLUL
GOLGA2
GRHL2
GRM8
GTF2I
GTF2IRD1
HDAC3
HMBOX1
HMG20A
HMG20B
HMGXB4
HNRNPCL1
HNRNPUL1
HOMER1
HOOK1
HUWE1
IKZF1
IMPDH1
JUN
KIFC3
LCE1E
LCE2C
LMNA
LMNB1
MAPK8
MAPKAPK2
MBD1
MITF
MLX
MSX2
MX1
MX2
NAV2
NME7
NR3C1
PAICS
PARK7
PAXIP1
PGR
PHC1
PIAS1
PIAS4
PLAG1
PLAGL1
PML
PRKAB2
PRKRA
PRPH
RFX2
RUFY1
RUNX1T1
SEC23A
SIAH1
SIAH2
SMAD3
SMAD4
SNAI2
SNIP1
SOX5
SPATC1L
SPINDOC
SREBF2
STAT4
SUMO1
SUMO1P1
SUMO2
SUMO3
SYN3
TH
TICAM2
TP53
TRAF2
TRAF3
TRAF5
TRIM23
TRIM27
TRIM50
TRIM55
TRIM63
TSR2
TXLNA
UBASH3B
UBE2I
UBE2L3
UBQLN1
ZBED1
ZBTB16
ZBTB8A
ZC3H10
ZFP42
ZNF319
ZNF451
ZNRD2
11 interacting genes:
ADORA1
ADORA2A
ADORA2B
DPP4
DRD1
GRB2
NR3C1
PIAS2
SGCD
TERF2IP
TINF2
Entrez ID
9063
100
HPRD ID
06944
00038
Ensembl ID
ENSG00000078043
ENSG00000196839
Uniprot IDs
A0A024RC49
O75928
Q2TA77
A0A0S2Z381
F5GWI4
P00813
PDB IDs
2ASQ
4FO9
1M7M
3IAR
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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