HUWE1 and CCL1

Data Source:
HPRD (in vitro)

		HUWE1	CCL1
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	C-C motif chemokine ligand 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Neutrophil Chemotaxis Positive Regulation Of Interleukin-17 Production Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Monocyte Chemotaxis
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)	Crohn's disease ( 22412388)
Interacting Genes		36 interacting genes: ABL1 ATOH1 CALM1 CCL1 CDKN2A CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2	3 interacting genes: CCR8 CXCL11 HUWE1
Entrez ID		10075	6346
HPRD ID		06608	01654
Ensembl ID		ENSG00000086758	ENSG00000108702
Uniprot IDs		A0A024R9W5 Q7Z6Z7	P22362
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL	1EL0 4OIJ 4OIK
Enriched GO Terms of Interacting Partners?
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