PIAS2 and PRKRA

Data Source:
BioGRID (two hybrid)

		PIAS2	PRKRA
Description		protein inhibitor of activated STAT 2	protein activator of interferon induced protein kinase EIF2AK2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway	Protein Phosphorylation Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus MiRNA Metabolic Process Viral Process Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Skeletal System Morphogenesis Regulation Of Catalytic Activity Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Fruit consumption ( 32066663)	Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)
Interacting Genes		125 interacting genes: ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CBSL CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2	28 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 LNX1 LYAR NKRF PIAS2 POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 STAU1 STRBP TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZMAT4 ZNF746
Entrez ID		9063	8575
HPRD ID		06944	04573
Ensembl ID		ENSG00000078043	ENSG00000180228
Uniprot IDs		A0A024RC49 O75928 Q2TA77	B4DJC7 O75569
PDB IDs		2ASQ 4FO9	2DIX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?