HUWE1 and H2AX

Data Source:
BioGRID (enzymatic study)

		HUWE1	H2AX
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	H2A.X variant histone
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Chromosome, Telomeric Region Nucleosome Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Centrosome Nuclear Speck Site Of Double-strand Break Extracellular Exosome Site Of DNA Damage
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Nucleosome Assembly Chromatin Silencing Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Viral Process Cerebral Cortex Development Positive Regulation Of DNA Repair Meiotic Cell Cycle Cellular Response To Gamma Radiation Cellular Senescence
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)
Interacting Genes		36 interacting genes: ABL1 ATOH1 CALM1 CCL1 CDKN2A CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2	46 interacting genes: A2M ACTB ALG9 ATM ATR BARD1 BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 EYA1 HUWE1 KAT5 MASP1 MDC1 MRE11 NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PRKDC PTPA QARS1 RNF168 RNF8 RPS6KA3 SMARCA4 SSRP1 SUPT16H SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TRAF6 TSSK6 WRN
Entrez ID		10075	3014
HPRD ID		06608	03465
Ensembl ID		ENSG00000086758	ENSG00000188486
Uniprot IDs		A0A024R9W5 Q7Z6Z7	P16104
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL	1YDP 2AZM 2D31 2DYP 3SHV 3SQD 3SZM 3U3Z 6K1I 6K1J 6K1K
Enriched GO Terms of Interacting Partners?
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