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PIAS2 and PIAS4
Data Source:
BioGRID
(two hybrid)
PIAS2
PIAS4
Description
protein inhibitor of activated STAT 2
protein inhibitor of activated STAT 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
PML Body
Transferase Complex
Molecular Function
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Protein Sumoylation
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Protein Sumoylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Sumoylation
Vitamin D Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Keratinocyte Apoptotic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Vitamin D (calciferol) metabolism
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Fruit consumption (
32066663
)
Chronic lymphocytic leukemia (
28165464
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
125 interacting genes:
ACY3
ADA
AKT1
AR
ATF2
C1QA
C5orf24
CBS
CBSL
CCHCR1
CCNDBP1
CDCA8
CGGBP1
CHMP4B
CLDN2
CREB1
CREBBP
CTBP1
DDX39B
DES
DEUP1
DMC1
DNMT3A
EDC3
ELK1
ESR1
ESR2
EXOSC8
FAM118B
FKBP6
FLI1
GFAP
GLUL
GOLGA2
GRHL2
GRM8
GTF2I
GTF2IRD1
HDAC3
HMBOX1
HMG20A
HMG20B
HMGXB4
HNRNPCL1
HNRNPUL1
HOMER1
HOOK1
HUWE1
IKZF1
IMPDH1
JUN
KIFC3
LCE1E
LCE2C
LMNA
LMNB1
MAPK8
MAPKAPK2
MBD1
MITF
MLX
MSX2
MX1
MX2
NAV2
NME7
NR3C1
PAICS
PARK7
PAXIP1
PGR
PHC1
PIAS1
PIAS4
PLAG1
PLAGL1
PML
PRKAB2
PRKRA
PRPH
RFX2
RUFY1
RUNX1T1
SEC23A
SIAH1
SIAH2
SMAD3
SMAD4
SNAI2
SNIP1
SOX5
SPATC1L
SPINDOC
SREBF2
STAT4
SUMO1
SUMO1P1
SUMO2
SUMO3
SYN3
TH
TICAM2
TP53
TRAF2
TRAF3
TRAF5
TRIM23
TRIM27
TRIM50
TRIM55
TRIM63
TSR2
TXLNA
UBASH3B
UBE2I
UBE2L3
UBQLN1
ZBED1
ZBTB16
ZBTB8A
ZC3H10
ZFP42
ZNF319
ZNF451
ZNRD2
85 interacting genes:
ACTN1
ALDOA
AR
AREL1
BARD1
BRCA1
BTAF1
CALCOCO2
CEBPD
CHD3
CLK1
COIL
ESRRA
FTH1
GADD45G
HDAC1
HDAC2
HNF4A
HNRNPUL1
HTT
IL15RA
IMMT
IMPDH2
IRF3
IRF7
KNTC1
KPNB1
KRT18
LAMP2
LCE1D
LEF1
LRIF1
MAGEH1
MAP1LC3A
MDC1
MPRIP
NEFL
NR4A2
OAZ1
OPTN
PARP1
PDE4A
PDE4D
PDE4DIP
PHF11
PHGDH
PIAS1
PIAS2
PLAG1
PRKCZ
PRPF40A
PTN
RIF1
SATB1
SERBP1
SERPINA5
SETDB1
SH3GL3
SKIL
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
SNAI2
SNIP1
SUMO1
SUMO2
SUMO3
TADA3
TCERG1
TICAM1
TOP2A
TP53
TRIM27
TRIM32
TRIM38
UBE2I
UBE2K
VHL
VIM
ZBTB34
ZHX1
ZNF512B
ZW10
Entrez ID
9063
51588
HPRD ID
06944
06910
Ensembl ID
ENSG00000078043
ENSG00000105229
Uniprot IDs
A0A024RC49
O75928
Q2TA77
B3KMR4
Q8N2W9
PDB IDs
2ASQ
4FO9
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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