HUWE1 and POLB

Data Source:
BioGRID (enzymatic study)

		HUWE1	POLB
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	DNA polymerase beta
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Microtubule Spindle Microtubule Protein-containing Complex
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Damaged DNA Binding DNA-directed DNA Polymerase Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Lyase Activity Enzyme Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion	In Utero Embryonic Development DNA-dependent DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Base-free Sugar-phosphate Removal Base-excision Repair, Gap-filling Base-excision Repair, DNA Ligation Pyrimidine Dimer Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Via Nonhomologous End Joining Inflammatory Response Cellular Response To DNA Damage Stimulus Salivary Gland Morphogenesis Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Somatic Hypermutation Of Immunoglobulin Genes Protein Deubiquitination Response To Ethanol Lymph Node Development Spleen Development Homeostasis Of Number Of Cells Neuron Apoptotic Process Response To Hyperoxia Immunoglobulin Heavy Chain V-D-J Recombination DNA Biosynthetic Process
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PCNA-Dependent Long Patch Base Excision Repair Ub-specific processing proteases Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Drugs			Cytarabine Iron dATP (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)	Plasma parathyroid hormone levels ( 30134803) Plasma plasminogen activator levels ( 24578379)
Interacting Genes		36 interacting genes: ABL1 ATOH1 CALM1 CCL1 CDKN2A CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2	19 interacting genes: APEX1 BRCA1 EP300 HUS1 HUWE1 KAT7 NEIL1 PCNA PNKP PRKCA RAD1 RAD9A SRPK2 STUB1 TAF1D TLE1 TPP2 WRN XRCC1
Entrez ID		10075	5423
HPRD ID		06608	07517
Ensembl ID		ENSG00000086758	ENSG00000070501
Uniprot IDs		A0A024R9W5 Q7Z6Z7	B7Z1W5 P06746
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL	1BPX 1BPY 1BPZ 1MQ2 1MQ3 1TV9 1TVA 1ZJM 1ZJN 1ZQA 1ZQB 1ZQC 1ZQD 1ZQE 1ZQF 1ZQG 1ZQH 1ZQI 1ZQJ 1ZQK 1ZQL 1ZQM 1ZQN 1ZQO 1ZQP 1ZQQ 1ZQR 1ZQS 1ZQT 2FMP 2FMQ 2FMS 2I9G 2ISO 2ISP 2P66 2PXI 3C2K 3C2L 3C2M 3GDX 3ISB 3ISC 3ISD 3JPN 3JPO 3JPP 3JPQ 3JPR 3JPS 3JPT 3LK9 3MBY 3OGU 3RH4 3RH5 3RH6 3RJE 3RJF 3RJG 3RJH 3RJI 3RJJ 3RJK 3TFR 3TFS 4DO9 4DOA 4DOB 4DOC 4F5N 4F5O 4F5P 4F5Q 4F5R 4GXI 4GXJ 4GXK 4JWM 4JWN 4KLD 4KLE 4KLF 4KLG 4KLH 4KLI 4KLJ 4KLL 4KLM 4KLO 4KLQ 4KLS 4KLT 4KLU 4LVS 4M2Y 4M47 4M9G 4M9H 4M9J 4M9L 4M9N 4MF2 4MF8 4MFA 4MFC 4MFF 4NLK 4NLN 4NLZ 4NM1 4NM2 4NXZ 4NY8 4O5C 4O5E 4O5K 4O9M 4P2H 4PGQ 4PGX 4PGY 4PH5 4PHA 4PHD 4PHE 4PHP 4PPX 4R63 4R64 4R65 4R66 4RPX 4RPY 4RPZ 4RQ0 4RQ1 4RQ2 4RQ3 4RQ4 4RQ5 4RQ6 4RQ7 4RQ8 4RT2 4RT3 4TUP 4TUQ 4TUR 4TUS 4UAW 4UAY 4UAZ 4UB1 4UB2 4UB3 4UB4 4UB5 4UBB 4UBC 4YMM 4YMN 4YMO 4YN4 4Z6C 4Z6D 4Z6E 4Z6F 5BOL 5BOM 5BPC 5DB6 5DB7 5DB8 5DB9 5DBA 5DBB 5DBC 5EOZ 5HHH 5HHI 5J0O 5J0P 5J0Q 5J0R 5J0S 5J0T 5J0U 5J0W 5J0X 5J0Y 5J29 5J2A 5J2B 5J2C 5J2D 5J2E 5J2F 5J2G 5J2H 5J2I 5J2J 5J2K 5TB8 5TB9 5TBA 5TBB 5TBC 5TZV 5U2R 5U2S 5U2T 5U8G 5U8H 5U8I 5U9H 5UGN 5UGO 5UGP 5V1F 5V1G 5V1H 5V1I 5V1J 5V1N 5V1O 5V1P 5V1R 5VEZ 5VRW 5VRX 5VRY 5VRZ 5VS0 5VS1 5VS2 5VS3 5VS4 5WNX 5WNY 5WNZ 5WO0 6BEL 6BEM 6BTE 6BTF 6CLY 6CPQ 6CR3 6CR4 6CR5 6CR6 6CR7 6CR8 6CR9 6CRB 6CRC 6CRH 6CTI 6CTJ 6CTK 6CTL 6CTM 6CTN 6CTO 6CTP 6CTQ 6CTR 6CTT 6CTU 6CTV 6CTW 6CTX 6CU9 6CUA 6CUB 6DIA 6DIC 6E3R 6E3V 6E3W 6E3X 6G2Q 6MR7 6MR8 6N2R 6N2S 6N2T 6NKR 6NKS 6NKT 6NKU 6NKV 6NKW 6NKX 6NKY 6NKZ 6NL0 6PH5 6PH6 6PKZ 6U2O 6U6B 6UOK 6UOL 6UOM 6W2M 7ICE 7ICF 7ICG 7ICH 7ICI 7ICJ 7ICK 7ICL 7ICM 7ICN 7ICO 7ICP 7ICQ 7ICR 7ICS 7ICT 7ICU 7ICV 8ICA 8ICB 8ICC 8ICE 8ICF 8ICG 8ICH 8ICI 8ICJ 8ICK 8ICL 8ICM 8ICN 8ICO 8ICP 8ICQ 8ICR 8ICS 8ICT 8ICU 8ICV 8ICW 8ICX 8ICY 8ICZ 9ICA 9ICB 9ICC 9ICE 9ICF 9ICG 9ICH 9ICI 9ICJ 9ICK 9ICL 9ICM 9ICN 9ICO 9ICP 9ICQ 9ICR 9ICS 9ICT 9ICU 9ICV 9ICW 9ICX 9ICY
Enriched GO Terms of Interacting Partners?
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