PSTPIP1 and MEFV

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		PSTPIP1	MEFV
Description		proline-serine-threonine phosphatase interacting protein 1	MEFV innate immuity regulator, pyrin
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GO Annotations	Cellular Component	Uropod Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle
	Molecular Function	Protein Binding Identical Protein Binding Actin Filament Binding	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Actin Filament Polymerization Innate Immune Response	Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome	Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Ankylosing spondylitis ( 30946743)
Interacting Genes		64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688	12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1
Entrez ID		9051	4210
HPRD ID		05891	02012
Ensembl ID		ENSG00000140368	ENSG00000103313
Uniprot IDs		A0A0S2Z5P3 O43586	D2DTW2 O15553
PDB IDs		2DIL	2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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