PSTPIP1 and FBXL18

Data Source:
BioGRID (two hybrid)

		PSTPIP1	FBXL18
Description		proline-serine-threonine phosphatase interacting protein 1	F-box and leucine rich repeat protein 18
Image			No pdb structure
GO Annotations	Cellular Component	Uropod Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Actin Filament Polymerization Innate Immune Response	Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Basophil percentage of white cells ( 32888494) Glomerular filtration rate in chronic kidney disease ( 26420894) High light scatter reticulocyte count ( 32888494) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Relative hand skill in reading disability ( 24068947)
Interacting Genes		64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688	22 interacting genes: CALCOCO2 FBXL7 FHL3 GOLGA2 HNRNPK KRT40 KRTAP10-3 KRTAP4-12 MDFI MID2 MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSMA3 PSTPIP1 RBPMS TFCP2 TRAF1 TRAF4 WWP1 WWP2
Entrez ID		9051	80028
HPRD ID		05891	07753
Ensembl ID		ENSG00000140368	ENSG00000155034
Uniprot IDs		A0A0S2Z5P3 O43586	A0A024R857 B4DH63 Q96D16
PDB IDs		2DIL
Enriched GO Terms of Interacting Partners?
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