MEFV and LGALS8

Data Source:
BioGRID (pull down)

		MEFV	LGALS8
Description		MEFV innate immuity regulator, pyrin	galectin 8
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Integrin Binding Protein Binding Carbohydrate Binding
	Biological Process	Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity	Cellular Response To Virus Xenophagy Lymphatic Endothelial Cell Migration
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)	Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	20 interacting genes: APEH BARD1 CALCOCO2 ERBB2 ITGA3 ITGA4 ITGB1 LRRK2 MEFV MID2 NACC1 NR1D2 TAX1BP1 TRIM17 TRIM22 TRIM23 TRIM49 TRIM5 TRIM6 WBP2
Entrez ID		4210	3964
HPRD ID		02012	09356
Ensembl ID		ENSG00000103313	ENSG00000116977
Uniprot IDs		D2DTW2 O15553	O00214
PDB IDs		2MPC 2WL1 4CG4	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z
Enriched GO Terms of Interacting Partners?
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