MEFV

Description		MEFV innate immuity regulator, pyrin
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1
Entrez ID		4210
HPRD ID		02012
Ensembl ID		ENSG00000103313
Uniprot IDs		D2DTW2 O15553
PDB IDs		2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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