MEFV and MAP1LC3C

Data Source:
BioGRID (pull down)

		MEFV	MAP1LC3C
Description		MEFV innate immuity regulator, pyrin	microtubule associated protein 1 light chain 3 gamma
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle	Autophagosome Membrane Autophagosome Cytosol Microtubule Endomembrane System Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding
	Biological Process	Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity	Autophagosome Assembly Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Macroautophagy
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)	Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	32 interacting genes: AMBRA1 ANK2 ANK3 ATG13 ATG4B ATXN3 CALCOCO2 CAPN3 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NEDD4 OPRM1 OPTN RHOXF1 RUFY4 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM32 TSR2 WDFY3 WDR81 ZNF24
Entrez ID		4210	440738
HPRD ID		02012	14226
Ensembl ID		ENSG00000103313	ENSG00000197769
Uniprot IDs		D2DTW2 O15553	Q9BXW4
PDB IDs		2MPC 2WL1 4CG4	2NCN 3VVW 3WAM 3WAP 5DPW
Enriched GO Terms of Interacting Partners?
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