CPNE1 and UBE2M

Data Source:
HPRD (in vitro)

		CPNE1	UBE2M
Description		copine 1	ubiquitin conjugating enzyme E2 M
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity
	Biological Process	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation
Pathways		Glycerophospholipid biosynthesis Neutrophil degranulation	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Theophylline
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		20 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SORBS3 SPTBN1 STK3 UBE2M UBE2O WTAP	30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		8904	9040
HPRD ID		05014	04414
Ensembl ID		ENSG00000214078	ENSG00000130725
Uniprot IDs		B0QZ18 Q99829	A0A024R4T4 P61081
PDB IDs			1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?
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