UBE2M and DCUN1D5

Data Source:
BioGRID (pull down)

		UBE2M	DCUN1D5
Description		ubiquitin conjugating enzyme E2 M	defective in cullin neddylation 1 domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Spindle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation	Regulation Of Cell Growth Cellular Response To DNA Damage Stimulus Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Interleukin-10 levels ( 22205395) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)
Interacting Genes		30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	11 interacting genes: CAND1 CHUK CUL2 CUL3 HUS1 LNX1 PICK1 PLEKHG4 RCHY1 UBE2F UBE2M
Entrez ID		9040	84259
HPRD ID		04414	14520
Ensembl ID		ENSG00000130725	ENSG00000137692
Uniprot IDs		A0A024R4T4 P61081	A0A024R3A2 B4DP84 Q9BTE7
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?
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