UBE2M and CUL7

Data Source:
BioGRID (enzymatic study)

		UBE2M	CUL7
Description		ubiquitin conjugating enzyme E2 M	cullin 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cullin-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Golgi Organization Regulation Of Mitotic Nuclear Division Viral Process Protein Ubiquitination IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			3M syndrome
GWAS		Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	9 interacting genes: COMMD1 FBXW8 MEGF10 MTDH MTNR1A PLXNB3 RBX1 SKP1 UBE2M
Entrez ID		9040	9820
HPRD ID		04414	09901
Ensembl ID		ENSG00000130725	ENSG00000044090
Uniprot IDs		A0A024R4T4 P61081	Q14999
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	2JNG
Enriched GO Terms of Interacting Partners?
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