UBE2M and DCUN1D4

Data Source:
BioGRID (pull down)

		UBE2M	DCUN1D4
Description		ubiquitin conjugating enzyme E2 M	defective in cullin neddylation 1 domain containing 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Ubiquitin Ligase Complex Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation	Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Estimated glomerular filtration rate ( 31152163) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196)
Interacting Genes		30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	7 interacting genes: CAND1 CUL2 CUL3 CUL4A CUL4B UBE2M VAV2
Entrez ID		9040	23142
HPRD ID		04414	13791
Ensembl ID		ENSG00000130725	ENSG00000109184
Uniprot IDs		A0A024R4T4 P61081	B4DH26 Q92564
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	5V89
Enriched GO Terms of Interacting Partners?
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