CPNE1 and WTAP

Data Source:
HPRD (in vitro)

		CPNE1	WTAP
Description		copine 1	WT1 associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Nuclear Membrane RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding	Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Cell Cycle Multicellular Organism Development RNA Splicing RNA Metabolic Process MRNA Methylation
Pathways		Glycerophospholipid biosynthesis Neutrophil degranulation	Processing of Capped Intron-Containing Pre-mRNA
Drugs		Theophylline
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Erosive tooth wear (severe vs non-severe) ( 29898447) Iron status biomarkers ( 19084217)
Interacting Genes		20 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SORBS3 SPTBN1 STK3 UBE2M UBE2O WTAP	15 interacting genes: ABHD15 BYSL CPNE1 IKZF1 MAGEA11 PSMA1 SLIRP TAB1 TCF12 TNIP1 VPS52 WT1 YWHAQ ZNF239 ZNF572
Entrez ID		8904	9589
HPRD ID		05014	09259
Ensembl ID		ENSG00000214078	ENSG00000146457
Uniprot IDs		B0QZ18 Q99829	A0A087X1R4 Q15007
PDB IDs
Enriched GO Terms of Interacting Partners?
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