CPNE1 and LHX6

Data Source:
BioGRID (two hybrid)

		CPNE1	LHX6
Description		copine 1	LIM homeobox 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension	Regulation Of Transcription By RNA Polymerase II Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Tangential Migration Cerebral Cortex GABAergic Interneuron Migration Forebrain Neuron Development Neuron Differentiation Cell Maturation
Pathways		Glycerophospholipid biosynthesis Neutrophil degranulation
Drugs		Theophylline
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Malaria ( 31844061)
Interacting Genes		20 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SORBS3 SPTBN1 STK3 UBE2M UBE2O WTAP	9 interacting genes: CPNE1 FAM90A1 FIGLA KLF3 LDB1 NRF1 ROR2 ZNF138 ZNF76
Entrez ID		8904	26468
HPRD ID		05014	10498
Ensembl ID		ENSG00000214078	ENSG00000106852
Uniprot IDs		B0QZ18 Q99829	A0A024R852 Q9UPM6
PDB IDs
Enriched GO Terms of Interacting Partners?
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