SGPL1 and STX4

Data Source:
BioGRID (two hybrid)

		SGPL1	STX4
Description		sphingosine-1-phosphate lyase 1	syntaxin 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Storage Vacuole Extracellular Space Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Endomembrane System Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Luteinization Vasculogenesis Ameboidal-type Cell Migration Kidney Development Fatty Acid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Positive Regulation Of Immunoglobulin Production Intracellular Protein Transport Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Positive Regulation Of Cell Population Proliferation Regulation Of Exocytosis Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Cellular Response To Interferon-gamma Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways		Sphingolipid de novo biosynthesis	Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
Drugs		Pyridoxal phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)
Interacting Genes		35 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TRARG1 TSPAN4 UNC50	72 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 EMD FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP29 SNAP47 STX10 STX11 STX12 STX16 STX1A STX1B STX2 STX3 STX5 STX6 STX7 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM199 TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VTI1B ZFPL1
Entrez ID		8879	6810
HPRD ID		07224	01722
Ensembl ID		ENSG00000166224	ENSG00000103496
Uniprot IDs		O95470	B7Z425 Q12846
PDB IDs		4Q6R
Enriched GO Terms of Interacting Partners?
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