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STX4 and STX5
Data Source:
BioGRID
(two hybrid, two hybrid)
STX4
STX5
Description
syntaxin 4
syntaxin 5
Image
No pdb structure
GO Annotations
Cellular Component
Storage Vacuole
Extracellular Space
Endosome
Vacuole
Trans-Golgi Network
Cytosol
Plasma Membrane
Synaptic Vesicle
Cell Surface
Endomembrane System
Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Lamellipodium
Phagocytic Vesicle Membrane
SNARE Complex
Myelin Sheath Adaxonal Region
Somatodendritic Compartment
Specific Granule
Dendritic Spine
Lateral Loop
Synapse
Perinuclear Region Of Cytoplasm
Presynaptic Active Zone Membrane
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Golgi Membrane
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Endomembrane System
ER To Golgi Transport Vesicle Membrane
Integral Component Of Membrane
SNARE Complex
Vesicle
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Molecular Function
SNARE Binding
SNAP Receptor Activity
Protein Binding
Sphingomyelin Phosphodiesterase Activator Activity
SNARE Binding
SNAP Receptor Activity
Protein Binding
Cadherin Binding
Protein N-terminus Binding
Biological Process
Positive Regulation Of Immunoglobulin Production
Intracellular Protein Transport
Exocytosis
Post-Golgi Vesicle-mediated Transport
Vesicle Fusion
Positive Regulation Of Cell Population Proliferation
Regulation Of Exocytosis
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Cellular Response To Oxidative Stress
SNARE Complex Assembly
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Catalytic Activity
Positive Regulation Of Eosinophil Degranulation
Positive Regulation Of Cell Adhesion
Vesicle Docking
Organelle Fusion
Positive Regulation Of Chemotaxis
Long-term Synaptic Potentiation
Cellular Response To Interferon-gamma
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Protein Localization To Plasma Membrane
Cornified Envelope Assembly
Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Positive Regulation Of Protein Localization To Cell Surface
Intracellular Protein Transport
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Vesicle Fusion
Early Endosome To Golgi Transport
Retrograde Transport, Endosome To Golgi
Positive Regulation Of Protein Catabolic Process
COPII Vesicle Coating
Vesicle Docking
Vesicle Fusion With Golgi Apparatus
Golgi Disassembly
Regulation Of Golgi Organization
Pathways
Disinhibition of SNARE formation
ER-Phagosome pathway
Translocation of SLC2A4 (GLUT4) to the plasma membrane
trans-Golgi Network Vesicle Budding
Other interleukin signaling
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-mediated anterograde transport
Intra-Golgi traffic
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS
Response to metformin (IC50) (
28173075
)
Triglyceride levels (
32203549
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
72 interacting genes:
ABI2
ACTB
ANKRD46
BET1
CYBRD1
DLG1
DNAJC5
EMD
FAXDC2
GIMAP5
GOSR2
GPR152
ITSN2
LLGL1
LMNA
NAPA
NAPB
NSF
PLP1
PSMA3
RAB11A
RAB4A
RAB5A
RNF4
SCRIB
SEC22A
SEC22B
SEPTIN5
SERP1
SGPL1
SH3GLB2
SNAP23
SNAP25
SNAP29
SNAP47
STX10
STX11
STX12
STX16
STX1A
STX1B
STX2
STX3
STX5
STX6
STX7
STX8
STXBP3
STXBP4
STXBP5
STXBP6
SYT1
SYT4
SYT7
TCEANC
TMEM199
TMEM203
TRAF3IP3
TXLNA
TXLNB
TXLNG
USE1
VAMP1
VAMP2
VAMP3
VAMP4
VAMP5
VAMP7
VAMP8
VAPB
VTI1B
ZFPL1
52 interacting genes:
AARD
APLP1
AQP6
BAG6
BET1
CCDC153
COPS6
CRB3
CREB3L3
EBP
FAM209A
GET3
GOSR1
GOSR2
GPANK1
GPR152
HAP1
HSD17B11
HSD17B13
IMMT
JAGN1
KASH5
LMNA
LNX1
LRIF1
LRRC4C
MAGEA6
MTUS1
NAPA
NAPB
NSFL1C
REEP4
RETREG3
SCFD1
SEC22B
SNAP23
SNAP25
STING1
STX1A
STX2
STX3
STX4
STX8
STXBP1
TACC1
TMEM31
TP53
USO1
VAMP5
VAPB
VCP
VCPIP1
Entrez ID
6810
6811
HPRD ID
01722
04426
Ensembl ID
ENSG00000103496
ENSG00000162236
Uniprot IDs
B7Z425
Q12846
B4DKR0
Q13190
PDB IDs
3EFO
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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