SGPL1 and RNASE10

Data Source:
BioGRID (two hybrid)

		SGPL1	RNASE10
Description		sphingosine-1-phosphate lyase 1	ribonuclease A family member 10 (inactive)
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Extracellular Region
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	Nucleic Acid Binding Ribonuclease Activity Protein Binding
	Biological Process	Luteinization Vasculogenesis Ameboidal-type Cell Migration Kidney Development Fatty Acid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Single Fertilization Positive Regulation Of Cell-cell Adhesion Heterotypic Cell-cell Adhesion Regulation Of Fertilization RNA Phosphodiester Bond Hydrolysis Positive Regulation Of Flagellated Sperm Motility
Pathways		Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Immune response to measles-mumps-rubella vaccine ( 24811271)
Interacting Genes		35 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TRARG1 TSPAN4 UNC50	6 interacting genes: BFSP2 CREB3L1 MRM1 SGPL1 SGTA SGTB
Entrez ID		8879	338879
HPRD ID		07224	18495
Ensembl ID		ENSG00000166224	ENSG00000182545
Uniprot IDs		O95470	Q5GAN6 W0UTC4
PDB IDs		4Q6R
Enriched GO Terms of Interacting Partners?
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