STX4 and STX10

Data Source:
BioGRID (two hybrid)

		STX4	STX10
Description		syntaxin 4	syntaxin 10
Image		No pdb structure
GO Annotations	Cellular Component	Storage Vacuole Extracellular Space Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Endomembrane System Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse	Trans-Golgi Network Cytosol Endomembrane System Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane SNARE Complex Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Intracellular Protein Transport Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Positive Regulation Of Cell Population Proliferation Regulation Of Exocytosis Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Cellular Response To Interferon-gamma Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Protein Localization To Cell Surface	Intracellular Protein Transport Vesicle Fusion Regulation Of Protein Localization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Vesicle Docking
Pathways		Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)	Venous thromboembolism ( 31420334)
Interacting Genes		72 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 EMD FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP29 SNAP47 STX10 STX11 STX12 STX16 STX1A STX1B STX2 STX3 STX5 STX6 STX7 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM199 TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VTI1B ZFPL1	5 interacting genes: COQ8A CXorf66 STX1A STX4 TMEM101
Entrez ID		6810	8677
HPRD ID		01722	04791
Ensembl ID		ENSG00000103496	ENSG00000104915
Uniprot IDs		B7Z425 Q12846	O60499 Q5U8S2 X6R2W0
PDB IDs			4DND
Enriched GO Terms of Interacting Partners?
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