POLA2 and STK40

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	STK40
Description		DNA polymerase alpha 2, accessory subunit	serine/threonine kinase 40
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Nucleoplasm Cytosol
	Molecular Function	Molecular_function DNA Binding Protein Binding	Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	Respiratory System Process Glycogen Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)	Neutrophil count ( 32888494)
Interacting Genes		33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1	7 interacting genes: APP COP1 COPS6 LRRK2 NEDD4L POLA2 SLIRP
Entrez ID		23649	83931
HPRD ID		10160	11359
Ensembl ID		ENSG00000014138	ENSG00000196182
Uniprot IDs		Q14181	Q8N2I9
PDB IDs		2KEB 4E2I 4Y97 5EXR	5L2Q
Enriched GO Terms of Interacting Partners?
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