POLA2 and XPNPEP1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	XPNPEP1
Description		DNA polymerase alpha 2, accessory subunit	X-prolyl aminopeptidase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Molecular_function DNA Binding Protein Binding	Aminopeptidase Activity Manganese Ion Binding Protein Homodimerization Activity Metalloaminopeptidase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	Proteolysis Bradykinin Catabolic Process
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)	Alcohol consumption (drinks per week) ( 30643258) Biliary atresia ( 20460270) Bipolar disorder ( 31043756 28072414) Refractive error ( 32231278)
Interacting Genes		33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1	12 interacting genes: DISC1 GORASP2 GSK3B HBG2 MAPK9 NUDT3 POLA2 RHOH RINT1 SUMO2 UBC UBE2D3
Entrez ID		23649	7511
HPRD ID		10160	03899
Ensembl ID		ENSG00000014138	ENSG00000108039
Uniprot IDs		Q14181	Q5T6H7 Q9NQW7
PDB IDs		2KEB 4E2I 4Y97 5EXR	3CTZ
Enriched GO Terms of Interacting Partners?
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