POLA2 and CRELD1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	CRELD1
Description		DNA polymerase alpha 2, accessory subunit	cysteine rich with EGF like domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Molecular_function DNA Binding Protein Binding	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	Endocardial Cushion Development Cardiac Septum Development Protein Phosphopantetheinylation
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Dacarbazine
Diseases			Atrioventricular septal defect; Atrioventricular canal defect
GWAS		Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)	Blood protein levels ( 30072576 29875488)
Interacting Genes		33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1	14 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HTR2C KAT5 MAP3K1 MTNR1B POLA2 PTN SETDB1 ZNF408
Entrez ID		23649	78987
HPRD ID		10160	06206
Ensembl ID		ENSG00000014138	ENSG00000163703
Uniprot IDs		Q14181	A0A024R2G1 Q96HD1
PDB IDs		2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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