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POLA2

Description DNA polymerase alpha 2, accessory subunit
Image
GO Annotations Cellular Component
  • Nucleoplasm
  • Alpha DNA Polymerase:primase Complex
  • Cytosol
Molecular Function
  • Molecular_function
  • DNA Binding
  • Protein Binding
Biological Process
  • G1/S Transition Of Mitotic Cell Cycle
  • DNA Replication
  • DNA Replication, Synthesis Of RNA Primer
  • DNA Replication Initiation
  • Telomere Maintenance Via Semi-conservative Replication
Pathways
  • Inhibition of replication initiation of damaged DNA by RB1/E2F1
  • Polymerase switching on the C-strand of the telomere
  • Telomere C-strand synthesis initiation
  • DNA replication initiation
  • Activation of the pre-replicative complex
  • Polymerase switching
  • Removal of the Flap Intermediate
  • Processive synthesis on the lagging strand
Drugs
  • Dacarbazine
Diseases
GWAS
  • Acne (severe) ( 24927181)
  • Serum uric acid levels ( 32514006)
Novel Interacting Genes 8 novel interacting genes: AGO2 ARL2 ATL3 CATSPERZ KDM2A SAC3D1 TMEM216 ZNRD2
Interacting Genes 33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID 23649
HPRD ID 10160
Ensembl ID ENSG00000014138
Uniprot IDs Q14181
PDB IDs 2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2023