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POLA2 and ATP5F1C
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
POLA2
ATP5F1C
Description
DNA polymerase alpha 2, accessory subunit
ATP synthase F1 subunit gamma
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Cytosol
Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Sector F(1)
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Proton-transporting ATP Synthase Complex
Mitochondrial Matrix
Membrane
Molecular Function
Molecular_function
DNA Binding
Protein Binding
RNA Binding
Protein Binding
ATPase Activity
Proton-transporting ATP Synthase Activity, Rotational Mechanism
Biological Process
G1/S Transition Of Mitotic Cell Cycle
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
Telomere Maintenance Via Semi-conservative Replication
Oxidative Phosphorylation
ATP Biosynthetic Process
ATP Synthesis Coupled Proton Transport
Cristae Formation
Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Formation of ATP by chemiosmotic coupling
Cristae formation
Drugs
Dacarbazine
Quercetin
1-ACETYL-2-CARBOXYPIPERIDINE
AUROVERTIN B
Piceatannol
N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
Diseases
GWAS
Acne (severe) (
24927181
)
Serum uric acid levels (
32514006
)
Interacting Genes
33 interacting genes:
AKTIP
APP
ASCC2
ATP5F1C
CPE
CRELD1
DCP2
DDX24
DHX34
EIF6
EZH2
FAM219A
FGFR3
FRZB
HDAC6
HELB
HGH1
IGFBP3
KCNE3
KLF6
LRPAP1
MFHAS1
NR4A1
PARP1
POLA1
PRIM2
PRPF38A
RBM23
SETDB1
SNU13
STK40
ULK2
XPNPEP1
29 interacting genes:
APP
ATP5F1A
ATP5F1B
CA12
CCND3
CCT7
CDC42
CHMP2B
DPP3
DUX4
EGFR
ELOF1
ERCC6
FBXO7
GDPD2
ITIH2
MED15
MEOX2
MPP1
NDUFB3
NGEF
PAWR
PJA1
PNO1
POLA2
PTEN
PTN
SERPINA1
ZNF337
Entrez ID
23649
509
HPRD ID
10160
00156
Ensembl ID
ENSG00000014138
ENSG00000165629
Uniprot IDs
Q14181
B4DL14
P36542
Q8TAS0
PDB IDs
2KEB
4E2I
4Y97
5EXR
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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