DOC2A and STXBP1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DOC2A	STXBP1
Description		double C2 domain alpha	syntaxin binding protein 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Lysosome Cell Junction Neuron Projection Extrinsic Component Of Synaptic Vesicle Membrane	Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding Protein N-terminus Binding
	Biological Process	Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Long-term Synaptic Depression Platelet Aggregation Cellular Response To Interferon-gamma Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Acrosomal Vesicle Exocytosis
Pathways			Regulation of insulin secretion Neurexins and neuroligins
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 28991256 25056061 29483656)	Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)
Interacting Genes		5 interacting genes: DYNLT1 RAP1GDS1 STXBP1 UBASH3B UNC13B	34 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SPICE1 SPTBN1 SQSTM1 STX19 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 USO1
Entrez ID		8448	6812
HPRD ID		05195	04235
Ensembl ID		ENSG00000149927	ENSG00000136854
Uniprot IDs		Q14183	P61764
PDB IDs		4MJJ	6L03
Enriched GO Terms of Interacting Partners?
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