DOC2A and RAP1GDS1

Data Source:
BioGRID (two hybrid)

		DOC2A	RAP1GDS1
Description		double C2 domain alpha	Rap1 GTPase-GDP dissociation stimulator 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Lysosome Cell Junction Neuron Projection Extrinsic Component Of Synaptic Vesicle Membrane	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding	GTPase Activator Activity Protein Binding
	Biological Process	Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 28991256 25056061 29483656)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		5 interacting genes: DYNLT1 RAP1GDS1 STXBP1 UBASH3B UNC13B	23 interacting genes: CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS MBIP NRAS PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451
Entrez ID		8448	5910
HPRD ID		05195	11763
Ensembl ID		ENSG00000149927	ENSG00000138698
Uniprot IDs		Q14183	B3KNU0 P52306 Q6U7G8
PDB IDs		4MJJ	5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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