DYRK3 and FBXO25

Data Source:
BioGRID (enzymatic study)

		DYRK3	FBXO25
Description		dual specificity tyrosine phosphorylation regulated kinase 3	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cytoplasmic Stress Granule Nuclear Speck Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Protein Phosphorylation Cell Cycle Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Erythrocyte Differentiation Nuclear Speck Organization Stress Granule Disassembly Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Division Regulation Of Cellular Response To Stress Positive Regulation Of Cell Cycle G2/M Phase Transition Organelle Disassembly Regulation Of TORC1 Signaling	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		4 interacting genes: FBXO25 GORASP2 NEDD4L PRNP	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		8444	26260
HPRD ID		04607	16439
Ensembl ID		ENSG00000143479	ENSG00000147364
Uniprot IDs		O43781	A0A024QZ88 Q8TCJ0
PDB IDs		5Y86
Enriched GO Terms of Interacting Partners?
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