VPS25 and VPS36

Data Source:
HPRD (two hybrid, in vivo)

		VPS25	VPS36
Description		vacuolar protein sorting 25 homolog	vacuolar protein sorting 36 homolog
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GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Extracellular Exosome	ESCRT II Complex Nucleus Endosome Cytosol Late Endosome Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity Protein N-terminus Binding	Protein Binding Protein C-terminus Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Endosomal Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Endosomal Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS			Lewy body disease ( 25188341)
Interacting Genes		21 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 VPS36	7 interacting genes: CHMP6 RILP SNF8 SPRY2 TSG101 UBC VPS25
Entrez ID		84313	51028
HPRD ID		14396	12620
Ensembl ID		ENSG00000131475	ENSG00000136100
Uniprot IDs		A0A024R1X3 Q9BRG1	Q86VN1
PDB IDs		2ZME 3CUQ 3HTU	2HTH 2ZME 3CUQ
Enriched GO Terms of Interacting Partners?
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