VPS36 and CHMP6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		VPS36	CHMP6
Description		vacuolar protein sorting 36 homolog	charged multivesicular body protein 6
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GO Annotations	Cellular Component	ESCRT II Complex Nucleus Endosome Cytosol Late Endosome Membrane Extracellular Exosome	ESCRT III Complex Multivesicular Body Cytosol Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding	Protein Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Endosomal Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Vesicle Budding From Membrane Nucleus Organization Mitotic Metaphase Plate Congression Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Protein Catabolic Process Midbody Abscission Regulation Of Exosomal Secretion ESCRT III Complex Assembly
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Lewy body disease ( 25188341)
Interacting Genes		7 interacting genes: CHMP6 RILP SNF8 SPRY2 TSG101 UBC VPS25	7 interacting genes: CHMP4A CHMP4B ELOF1 METTL9 SNF8 VPS25 VPS36
Entrez ID		51028	79643
HPRD ID		12620	08564
Ensembl ID		ENSG00000136100	ENSG00000176108
Uniprot IDs		Q86VN1	Q96FZ7
PDB IDs		2HTH 2ZME 3CUQ	2K3W 3HTU
Enriched GO Terms of Interacting Partners?
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