VPS25 and ASPG

Data Source:
BioGRID (two hybrid)

		VPS25	ASPG
Description		vacuolar protein sorting 25 homolog	asparaginase
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Extracellular Exosome	Cytosol
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity Protein N-terminus Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Asparaginase Activity Lysophospholipase Activity Protein Binding Transferase Activity, Transferring Acyl Groups Other Than Amino-acyl Groups Phosphatidyl Phospholipase B Activity
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Endosomal Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Cellular Amino Acid Biosynthetic Process Lipid Catabolic Process
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Aspartate and asparagine metabolism
Drugs			Procaine
Diseases
GWAS			Blood metabolite levels ( 24816252) Body mass index ( 26426971) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free asparagine levels ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		21 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 VPS36	12 interacting genes: C20orf85 CEACAM6 DMRT3 GSDMD MYOZ3 RTP5 SGK1 SHC3 TEKT3 TMEM115 USP2 VPS25
Entrez ID		84313	374569
HPRD ID		14396	19180
Ensembl ID		ENSG00000131475	ENSG00000166183
Uniprot IDs		A0A024R1X3 Q9BRG1	Q86U10
PDB IDs		2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?
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