VPS25 and APIP

Data Source:
HPRD (two hybrid)

		VPS25	APIP
Description		vacuolar protein sorting 25 homolog	APAF1 interacting protein
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GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity Protein N-terminus Binding	Protein Binding Zinc Ion Binding Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Endosomal Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Apoptotic Process L-methionine Salvage From S-adenosylmethionine L-methionine Salvage From Methylthioadenosine Negative Regulation Of Apoptotic Process Protein Homotetramerization Pyroptosis Regulation Of ERK1 And ERK2 Cascade
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Formation of apoptosome Methionine salvage pathway Regulation of the apoptosome activity
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010) Lung disease severity in cystic fibrosis ( 26417704) Prostate-specific antigen levels ( 28139693) Systemic lupus erythematosus ( 19838195)
Interacting Genes		21 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 VPS36	19 interacting genes: APAF1 BAZ2B CFAP206 GORASP2 IMPDH2 LNX1 NIF3L1 NTAQ1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 TSC22D4 VIM VPS25 ZBTB25
Entrez ID		84313	51074
HPRD ID		14396	14725
Ensembl ID		ENSG00000131475	ENSG00000149089
Uniprot IDs		A0A024R1X3 Q9BRG1	Q96GX9
PDB IDs		2ZME 3CUQ 3HTU	4M6R
Enriched GO Terms of Interacting Partners?
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