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PLEKHB2 and UBB
Data Source:
BioGRID
(two hybrid)
PLEKHB2
UBB
Description
pleckstrin homology domain containing B2
ubiquitin B
Image
GO Annotations
Cellular Component
Integral Component Of Membrane
Recycling Endosome Membrane
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Endocytic Vesicle Membrane
Vesicle
Neuron Projection
Neuronal Cell Body
Host Cell
Extracellular Exosome
Molecular Function
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Protein Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Biological Process
Regulation Of Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPK Activity
Protein Polyubiquitination
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Protein Targeting To Peroxisome
Male Meiosis I
Female Meiosis I
Transforming Growth Factor Beta Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Female Gonad Development
Wnt Signaling Pathway
Endosomal Transport
Protein Ubiquitination
Protein Deubiquitination
Viral Life Cycle
Virion Assembly
Cytokine-mediated Signaling Pathway
Modification-dependent Protein Catabolic Process
Translesion Synthesis
Hypothalamus Gonadotrophin-releasing Hormone Neuron Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Protein Ubiquitination
Nucleotide-excision Repair, DNA Incision
TRIF-dependent Toll-like Receptor Signaling Pathway
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Cellular Protein Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Mitochondrion Transport Along Microtubule
Neuron Projection Morphogenesis
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Regulation Of Mitochondrial Membrane Potential
Transmembrane Transport
Fat Pad Development
Membrane Organization
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Global Genome Nucleotide-excision Repair
Error-free Translesion Synthesis
Seminiferous Tubule Development
Intracellular Transport Of Virus
Energy Homeostasis
Regulation Of Neuron Death
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Monoubiquitination
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
Circadian Clock
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Maturation of protein E
Maturation of protein E
Negative regulation of FLT3
FLT3 signaling by CBL mutants
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(4s)-5-Fluoro-L-Leucine
Diseases
GWAS
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Interacting Genes
49 interacting genes:
ATF7IP
BHLHE40
C1orf94
CD68
CDA
CLDN19
DAZAP2
DCUN1D1
EMP1
EMP3
EPN1
EPN2
FAM168A
FOXD4L3
GGA3
GJB2
GLIS2
HEY1
HEYL
HGS
HIVEP1
MAP3K1
MED25
MTURN
NTAQ1
OTUB2
PIP4P1
PITX1
POGZ
PROP1
RHBDD1
RPS27A
SFT2D1
SNRPB
STAM2
SYNGR1
TAX1BP1
TRARG1
UBA52
UBAC1
UBAP2
UBASH3A
UBB
UBC
UBQLN2
UBXN6
UPF1
YOD1
ZFAND2A
81 interacting genes:
APP
ATXN3
BIRC2
BRAP
BRCA1
CDC25A
CDC34
CDIP1
CDKN1B
CDT1
CDX2
CHEK1
DAZAP2
DESI1
DNMT1
DUSP1
ECT2
EGFR
ELF4
EPS15
ERBB2
FANCD2
FSHR
HDAC6
HGS
HLA-A
IKBKB
IKBKG
JUN
LIG4
LYN
MAPT
MDM2
MTURN
MYBL2
MYC
NR3C1
NTRK1
NTRK2
OPTN
PCNA
PIN1
PLEKHB2
PLSCR4
POLI
PRKN
PSMD4
RABGEF1
RAD23A
RAD23B
RNF11
SDCBP
SH3KBP1
SKP2
SMAD4
SMURF1
SNCA
SNCAIP
SQSTM1
STUB1
SYK
TAX1BP1
TGFBR1
TP53
TRAF6
TRIM37
TRIM5
UBAC1
UBASH3A
UBASH3B
UBE2D2
UBE2K
UBE2N
UBE2S
UBQLN1
UBQLN2
UIMC1
USP1
USP30
WWOX
XIAP
Entrez ID
55041
7314
HPRD ID
15144
06771
Ensembl ID
ENSG00000115762
ENSG00000170315
Uniprot IDs
A0A024QZ35
A0A0A0MSE9
A0A0A0MSI4
B4DJB7
Q96CS7
P0CG47
Q5U5U6
PDB IDs
3AJ4
3VIA
2KHW
2MBB
2MRO
2MSG
2N13
4UEL
4UF6
4WHV
4WLR
4WUR
4XOF
4ZFR
4ZFT
4ZPZ
4ZUX
5BNB
5CAW
5CRA
5CVM
5CVN
5CVO
5D0K
5D0M
5DFL
5DK8
5E6J
5EDV
5EMZ
5EYA
5GJQ
5GO7
5GO8
5GOB
5GOC
5GOD
5GOG
5GOH
5GOI
5GOJ
5GOK
5H7S
5IBK
5IFR
5JBY
5JG6
5JP3
5JTJ
5JTV
5K9P
5KGF
5KHY
5KYC
5KYD
5KYE
5KYF
5L8H
5L8W
5L9T
5LN1
5LRV
5LRW
5LRX
5M93
5MNJ
5N2W
5N38
5NL5
5NLJ
5NVG
5O44
5O6T
5OHK
5OHL
5OHN
5OHP
5TOF
5TOG
5TUT
5TXK
5UJL
5UJN
5ULF
5ULH
5ULK
5V1Y
5V1Z
5VEY
5VF0
5VNZ
5VO0
5VZM
5VZW
5W46
5WFI
5X3M
5X3N
5X3O
5XBO
5XDP
5XK4
5XK5
5XPK
5YDR
5YIJ
5YIK
5YMY
5YT6
5ZBU
5ZD0
6ASR
6BVA
6BYH
6C16
6CP2
6DGF
6EI1
6FDK
6FGE
6FTX
6FX4
6FYH
6GLC
6GZS
6H4H
6HEI
6HEK
6IF1
6ISU
6JB6
6JB7
6JMA
6K4I
6K9P
6KOW
6KOX
6MSB
6MSD
6MSE
6MSG
6N13
6NJG
6O96
6OAM
6PGV
6QF8
6QK9
6QML
6TBM
6UH5
6XAA
7CAP
7JMS
Enriched GO Terms of Interacting Partners
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