PLEKHB2 and CDA

Data Source:
BioGRID (two hybrid)

		PLEKHB2	CDA
Description		pleckstrin homology domain containing B2	cytidine deaminase
Image
GO Annotations	Cellular Component	Integral Component Of Membrane Recycling Endosome Membrane	Extracellular Region Cytosol Secretory Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding	Nucleoside Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Cell Differentiation	Cell Surface Receptor Signaling Pathway Pyrimidine-containing Compound Salvage Cytidine Deamination Cytosine Metabolic Process Negative Regulation Of Cell Growth Pyrimidine Nucleoside Salvage Neutrophil Degranulation Negative Regulation Of Nucleotide Metabolic Process
Pathways			Neutrophil degranulation Pyrimidine salvage
Drugs			1-Beta-Ribofuranosyl-1,3-Diazepinone Cedazuridine
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Basophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		49 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A	18 interacting genes: ADAT3 ARRDC3 DDIT4L FNDC11 FOXN1 GORASP2 INCA1 KPNA2 KRTAP6-1 KRTAP8-1 LNX1 NTAQ1 PLEKHB2 PSMA1 PTGER3 SDCBP ZBTB24 ZNF598
Entrez ID		55041	978
HPRD ID		15144	11744
Ensembl ID		ENSG00000115762	ENSG00000158825
Uniprot IDs		A0A024QZ35 A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7	P32320
PDB IDs		3AJ4 3VIA	1MQ0
Enriched GO Terms of Interacting Partners?
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