BCAR3 and SERPINB5

Data Source:
BioGRID (two hybrid)

		BCAR3	SERPINB5
Description		BCAR3 adaptor protein, NSP family member	serpin family B member 5
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GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Membrane	Extracellular Space Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelin Receptor Signaling Pathway	Morphogenesis Of An Epithelium Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis
Pathways
Drugs			S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)
Interacting Genes		38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GAS8 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45	26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF SMAD4 STK11 TBP TKT UCHL5 XRCC3
Entrez ID		8412	5268
HPRD ID		05268	01111
Ensembl ID		ENSG00000137936	ENSG00000206075
Uniprot IDs		A0A384MTS3 B3KNL6 B3KP06 O75815	A0A024R2B6 P36952
PDB IDs		3T6A	1WZ9 1XQG 1XQJ 1XU8
Enriched GO Terms of Interacting Partners?
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