BCAR3 and CST6

Data Source:
BioGRID (two hybrid)

		BCAR3	CST6
Description		BCAR3 adaptor protein, NSP family member	cystatin E/M
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GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Membrane	Cornified Envelope Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelin Receptor Signaling Pathway	Epidermis Development Anatomical Structure Morphogenesis Negative Regulation Of Endopeptidase Activity
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340) Serum uric acid levels ( 32514006)
Interacting Genes		38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GAS8 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45	7 interacting genes: BCAR3 GSK3B NOTCH2 PALB2 RAD51 TGFB1 YIF1A
Entrez ID		8412	1474
HPRD ID		05268	03535
Ensembl ID		ENSG00000137936	ENSG00000175315
Uniprot IDs		A0A384MTS3 B3KNL6 B3KP06 O75815	Q15828
PDB IDs		3T6A	4N6L 4N6M 4N6N 4N6O 6FK0
Enriched GO Terms of Interacting Partners?
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