BCAR3 and MTA3

Data Source:
BioGRID (two hybrid)

		BCAR3	MTA3
Description		BCAR3 adaptor protein, NSP family member	metastasis associated 1 family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Membrane	Nucleoplasm Cytoplasm NuRD Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding	RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelin Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)	Breastfeeding duration ( 25475840)
Interacting Genes		38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GAS8 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45	21 interacting genes: AKT1 ARNT ATM AURKA BAG4 BCAR3 BCL6 CDKN2C ERCC6 FGFR2 FGFR4 FOXK2 FZR1 GRB2 IGF1R KDM1A NACC2 NOTCH2 PARP1 TGFB1 TSG101
Entrez ID		8412	57504
HPRD ID		05268	12359
Ensembl ID		ENSG00000137936	ENSG00000057935
Uniprot IDs		A0A384MTS3 B3KNL6 B3KP06 O75815	F6RRE2 Q9BTC8
PDB IDs		3T6A
Enriched GO Terms of Interacting Partners?
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