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SERPINB5 and COL1A2
Data Source:
BioGRID
(two hybrid, pull down)
SERPINB5
COL1A2
Description
serpin family B member 5
collagen type I alpha 2 chain
Image
GO Annotations
Cellular Component
Extracellular Space
Cytoplasm
Extracellular Region
Collagen Type I Trimer
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Protein-macromolecule Adaptor Activity
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Morphogenesis Of An Epithelium
Negative Regulation Of Endopeptidase Activity
Extracellular Matrix Organization
Regulation Of Epithelial Cell Proliferation
Prostate Gland Morphogenesis
Skeletal System Development
Blood Vessel Development
Transforming Growth Factor Beta Receptor Signaling Pathway
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Blood Pressure
Cytokine-mediated Signaling Pathway
Platelet Activation
Extracellular Matrix Organization
Collagen Fibril Organization
Bone Mineralization
Collagen Metabolic Process
Odontogenesis
Skin Morphogenesis
Regulation Of Immune Response
Leukocyte Migration
Protein Heterotrimerization
Cellular Response To Amino Acid Stimulus
Extracellular Matrix Assembly
Pathways
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Interleukin-4 and Interleukin-13 signaling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
Collagen chain trimerization
Drugs
S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Osteogenesis imperfecta
GWAS
Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) (
24025145
)
Aging (
22773346
)
Heel bone mineral density (
30598549
)
Immune reponse to smallpox (secreted IL-12p40) (
22610502
)
Intelligence (
22449649
)
Low bone mineral density (hip) (
26235824
)
Low bone mineral density (spine) (
26235824
)
Mean forced vital capacity from 2 exams (
17903307
)
Post bronchodilator FEV1 (
26634245
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Interacting Genes
26 interacting genes:
AKT1
ATIC
BASP1
BCAR3
CASP8
COL1A2
EEF1A1
ESR1
GOLGA4
GSTO1
HDAC1
HSP90AA1
HSP90AB1
HSPA5
KRAS
LRRFIP1
MDH1
MT1H
PALB2
PPIF
SMAD4
STK11
TBP
TKT
UCHL5
XRCC3
31 interacting genes:
APP
BGN
CD36
CD44
CD93
COL5A3
DCN
EIF3F
FN1
ITGA2
ITGA2B
ITGB3
KCNIP4
LIG4
LUM
MESD
MMP9
MYOC
P4HB
PDGFA
PDGFB
SERPINB5
SGTA
SGTB
SHBG
SMARCD1
SPARC
TGFBI
UBQLN1
UBQLN2
VWF
Entrez ID
5268
1278
HPRD ID
01111
00363
Ensembl ID
ENSG00000206075
ENSG00000164692
Uniprot IDs
A0A024R2B6
P36952
A0A0S2Z3H5
P08123
PDB IDs
1WZ9
1XQG
1XQJ
1XU8
5CTD
5CTI
5CVA
6JEC
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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