ARL6 and SEC61B

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ARL6	SEC61B
Description		ADP ribosylation factor like GTPase 6	SEC61 translocon subunit beta
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GO Annotations	Cellular Component	Cytoplasm Axonemal Microtubule Plasma Membrane Cilium Axoneme Membrane Membrane Coat Extracellular Exosome	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	RNA Binding Protein Binding Epidermal Growth Factor Binding
	Biological Process	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Visual Perception Wnt Signaling Pathway Vesicle-mediated Transport Melanosome Transport Protein Polymerization Cilium Assembly Protein Localization To Cilium	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity
Pathways		BBSome-mediated cargo-targeting to cilium	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)
GWAS		Male infertility ( 19478329)	Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B	19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A
Entrez ID		84100	10952
HPRD ID		10588	06715
Ensembl ID		ENSG00000113966	ENSG00000106803
Uniprot IDs		Q9H0F7	P60468
PDB IDs		2H57	6W6L
Enriched GO Terms of Interacting Partners?
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