SEC61B and MLH3

Data Source:
BioGRID (two hybrid)

		SEC61B	MLH3
Description		SEC61 translocon subunit beta	mutL homolog 3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	RNA Binding Protein Binding Epidermal Growth Factor Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A	45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		10952	27030
HPRD ID		06715	05094
Ensembl ID		ENSG00000106803	ENSG00000119684
Uniprot IDs		P60468	Q2M1Z1 Q9UHC1
PDB IDs		6W6L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?