SEC61B and ARL6

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		SEC61B	ARL6
Description		SEC61 translocon subunit beta	ADP ribosylation factor like GTPase 6
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GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Cytoplasm Axonemal Microtubule Plasma Membrane Cilium Axoneme Membrane Membrane Coat Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Epidermal Growth Factor Binding	GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Visual Perception Wnt Signaling Pathway Vesicle-mediated Transport Melanosome Transport Protein Polymerization Cilium Assembly Protein Localization To Cilium
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Male infertility ( 19478329)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A	6 interacting genes: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B
Entrez ID		10952	84100
HPRD ID		06715	10588
Ensembl ID		ENSG00000106803	ENSG00000113966
Uniprot IDs		P60468	Q9H0F7
PDB IDs		6W6L	2H57
Enriched GO Terms of Interacting Partners?
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