SEC61B and SEC63

Data Source:
HPRD (in vitro)

		SEC61B	SEC63
Description		SEC61 translocon subunit beta	SEC63 homolog, protein translocation regulator
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Sec62/Sec63 Complex
	Molecular Function	RNA Binding Protein Binding Epidermal Growth Factor Binding	RNA Binding Protein Binding Protein Transmembrane Transporter Activity Signaling Receptor Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity	Liver Development Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Nitrogen Compound Metabolic Process Multicellular Organism Aging Posttranslational Protein Targeting To Membrane, Translocation
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases			Polycystic liver disease
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction ( 32080893)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A	4 interacting genes: HSPA5 MEOX2 SEC61B SEC62
Entrez ID		10952	11231
HPRD ID		06715	09783
Ensembl ID		ENSG00000106803	ENSG00000025796
Uniprot IDs		P60468	A0A0S2Z5M1 Q9UGP8
PDB IDs		6W6L
Enriched GO Terms of Interacting Partners?
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