SEC61B and TRAM1

Data Source:
HPRD (in vivo)

		SEC61B	TRAM1
Description		SEC61 translocon subunit beta	translocation associated membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Endoplasmic Reticulum Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Binding Protein Binding Epidermal Growth Factor Binding	Protein Binding Signaling Receptor Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Viral Process Protein Insertion Into ER Membrane
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Cardiac Troponin-T levels ( 23247143) Erythrocyte cadmium concentration in never smokers ( 27005419) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A	12 interacting genes: APP CREB3 DRD2 ESR1 ESR2 GUCA2A SEC61B TICAM1 TIRAP TRAF6 UBC VKORC1
Entrez ID		10952	23471
HPRD ID		06715	05545
Ensembl ID		ENSG00000106803	ENSG00000067167
Uniprot IDs		P60468	G3XAN4 Q15629 Q6FHL3
PDB IDs		6W6L
Enriched GO Terms of Interacting Partners?
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