SEC61B and SPC25

Data Source:
HPRD (in vivo)

		SEC61B	SPC25
Description		SEC61 translocon subunit beta	SPC25 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Condensed Chromosome Kinetochore Nucleus Cytosol Ndc80 Complex
	Molecular Function	RNA Binding Protein Binding Epidermal Growth Factor Binding	Protein Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity	Mitotic Spindle Organization Chromosome Segregation Cell Division
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Circulating leptin levels or HOMA-B ( 32341051) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Fasting blood glucose ( 29621232) Glycemic traits (pleiotropy) ( 31021400) Granulocyte count ( 27863252) Height ( 28552196) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A	4 interacting genes: HGS NDC80 SEC61B SPC24
Entrez ID		10952	57405
HPRD ID		06715	15465
Ensembl ID		ENSG00000106803	ENSG00000152253
Uniprot IDs		P60468	Q9HBM1
PDB IDs		6W6L	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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