SPOP and ZBTB16

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SPOP	ZBTB16
Description		speckle type BTB/POZ protein	zinc finger and BTB domain containing 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcription Repressor Complex Protein-containing Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Mesonephros Development Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development
Pathways		Hedgehog 'on' state	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Skeletal defects, genital hypoplasia, and mental retardation Acute myeloid leukemia (AML)
GWAS		Prostate cancer ( 23535732)	Basophil count ( 32888494) Chronotype ( 30696823) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Corneal astigmatism ( 29422769) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443 26424050) Paneth cell defects in Crohn's disease ( 28352666) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Polycystic ovary syndrome ( 26284813 30566500) Red blood cell count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urinary albumin-to-creatinine ratio ( 32600054) White blood cell count ( 32888494 27863252)
Interacting Genes		66 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	154 interacting genes: ACP5 ADAMTS4 AGTR2 AMOTL2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BLZF1 BMI1 CARD9 CASP3 CCDC130 CCDC85B CCHCR1 CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COG6 COQ6 CTDSP1 DLST DNAAF5 DNM2 DPM1 EEF1A1 EFHC2 EIF2S2 ENOX1 EP300 EPN1 ERVK-6 ESR1 FAM217B FAM90A1 FCHO1 FHL2 FHL5 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GOLGA6L9 GPANK1 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX HOXA1 HOXC5 HSF2BP ICAM3 IL6 KIAA1549 KIFC3 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LRIG1 LSM2 LYAR MAGEA11 MAP3K3 MCUB MEOX2 MID2 MTUS2 MX1 MYLIP NCOR1 NCOR2 NFKBID NME4 NR3C1 OSBPL3 PAFAH1B3 PARP1 PGAM5 PHF1 PIAS2 PIBF1 PLSCR1 PMAIP1 PML PNRC2 PRKAR1B PSMD11 PSMD2 QTRT1 RAB27A RAB3IP RARA RB1 REL RFLNB RINT1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TLE5 TOLLIP TRAF1 TRAF2 TRAF4 TRIM21 TRIM23 TRIM27 TRIM54 TTC23 TXNIP UBE2I VDR VTA1 WASHC1 WDR33 ZBTB32 ZBTB42 ZNF24 ZNF281 ZNF552 ZNF620 ZNF655
Entrez ID		8405	7704
HPRD ID		16004	11762
Ensembl ID		ENSG00000121067	ENSG00000109906
Uniprot IDs		O43791	A0A024R3C6 Q05516
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A	1BUO 1CS3
Enriched GO Terms of Interacting Partners?
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